Lack of dystrophin influences muscle inflammation but not myogenic regulatory factors after eccentric exercise in mdx mice
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چکیده
منابع مشابه
Doxorubicin inhibits muscle inflammation after eccentric exercise
BACKGROUND Doxorubicin, a widely used anti-tumour drug, is known to cause muscle loss in cancer patients. METHODS Following an acute dose of doxorubicin injection (2.5 mg/kg per body weight), we examined macrophage distribution in rat soleus muscle challenged by eccentric exercise (downhill running). Long-term doxorubicin treatment (one injection every 3 days) on muscle mass and survival were...
متن کاملGender differences in muscle inflammation after eccentric exercise.
Unaccustomed exercise is followed by delayed-onset muscle soreness and morphological changes in skeletal muscle. Animal studies have demonstrated that women have an attenuated response to muscle damage. We studied the effect of eccentric exercise in untrained male (n = 8) and female (n = 8) subjects using a unilateral exercise design [exercise (Ex) and control (Con) legs]. Plasma granulocyte co...
متن کاملFish oil supplementation reduces markers of oxidative stress but not muscle soreness after eccentric exercise.
Due to the potential anti-inflammatory properties of fish-derived long chain n-3 fatty acids, it has been suggested that athletes should regularly consume fish oils-although evidence in support of this recommendation is not clear. While fish oils can positively modulate immune function, it remains possible that, due to their high number of double bonds, there may be concurrent increases in lipi...
متن کاملDystrophin and dystrophin-like proteins in muscle and brain of normal and mdx mice.
tions. Central nervous system (CNS) gp 130 is a major sialylated glycoprotein component of the CNS which is detectable at the synapse. This molecule is, however, heavily glycosylated and is detectable as a component of myelin (P. R. Gordon-Weeks, personal communication). Both immunocytochemical studies and Western blot analysis show that the present antigens are not myelin associated. Furthermo...
متن کاملStem Cells Restores Dystrophin in mdx Mice
Duchenne muscular dystrophy is a lethal recessive disease characterized by widespread muscle damage throughout the body. This increases the difficulty of cell or gene therapy based on direct injections into muscles. One way to circumvent this obstacle would be to use circulating cells capable of homing to the sites of lesions. Here, we showed that stem cell antigen 1 (Sca-1), CD34 double-positi...
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ژورنال
عنوان ژورنال: Motriz: Revista de Educação Física
سال: 2020
ISSN: 1980-6574
DOI: 10.1590/s1980-6574202000030228